Innovative nanomaterials for drug delivery
One of the most stubborn challenges facing the pharmaceutical industry is in the provision of drug efficacy without the concomitant side effects. Targeted drug delivery promises much by way of minimising the toxicity and off-target effects of pharmaceuticals, but development has been hindered by issues of poor solubility and restricted accessibility to areas of the body that are protected by the dermal layer and the blood brain barrier (BBB).
Mesoporous silica particles are attracting growing attention as functional biocompatible drug carriers which can deliver therapeutic agents to a target site in a controlled manner. In particular, sol-gel derived mesoporous silicas represent a novel formulation which combines the favourable chemical properties of silica, such as thermal stability and biocompatibility, with the advantages of the sol-gel route such as relative simplicity in production, modification and the ability to maintain function of bioactive agents.
Glantreo have developed platform technologies that allow the synthesis of these mesoporous particles. These technologies allow Glantreo to tune the relevant physical properties of the particles (particle size, pore size, surface area, and surface properties). In particular, the ability to activate the surface facilitates the incorporation of multiple drug molecules and controlled delivery to the target sites. In essence, Glantreo can provide the multifunctional drug delivery vehicles for smart and autonomous nanocarrier systems.
In delivering the correct solution to its Pharmaceutical clients, Glantreo would engage in a rigorous 5 step process thereby ensuring the delivery of a quality nanomaterial to its partner.